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2002/11/06

CAMIDA meets the chemical industy's needs on a global basis by offering a wide range of products, sourced through dedicated and meticulous research. CAMIDA is committed to delivering top-quality products to customers safely and on time. Click here for our complete profile. (Click to read latest camida newsletter) CAMIDA Ireland CAMIDA UK CAMIDA USA CAMIDA Singapore CAMIDA Holdings Ltd. info@camida.com Trouble difficulty finding a product or article? Please enter your search term below: Visit Camida at CPHI Paris, 3rd - 5th October 2006 , Hall 5 - Stand # 5A62. Visit Camida at Informex, San Francisco, 13th - 16th February 2007 at Booth # 365.

Markets

2001/13/11

Industries Camida's operational companies act as agents in their respective territories for a number of specialist overseas manufacturers. Each of these manufacturers is carefully selected and all have first class reputations. In addition, Camida welcomes enquiries for an unlimited range of non-commodity products. Camida serves the following industries: Pharmaceutical Agrochemical Biotechnology Diagnostic Food and Feed Surface Coating Fine chemical manufacture Petrochemical Electronic Resins

Terms & Conditions

2001/15/11

Conditions 1-9 inclusive apply where Camida acts as a vendor. Condition 10 applies where Camida acts as a purchaser. The term Camida in these conditions may refer to any of the Camida group of companies. That is: Camida Holdings Ltd Ireland Camida Ltd Ireland Camida Ltd UK Camida LLC USA Camida Pte Singapore 1. These conditions of sales shall apply to all quotations and deliveries made by Camida to its customers with the exception of those changes which have been expressly agreed to in writing by both parties. Where the customers purchasing conditions conflict with these conditions, these conditions shall apply. All agreements and promises, whether in conflict with these conditions or not, made by Camida representatives or staff will only be valid if expressly agreed to in writing. 2. Camida is never committed to any other offer or agreed time of delivery. Although the agreed times of delivery will be observed as much as possible, any liability of Camida due to non-delivery or delayed delivery is excluded. A delivery later than the agreed time delivery does not annul the customers obligations, unless the customer has annulled the order in writing for that reason. 3. Any complaints or claims in relation to the goods must be made within 8 days of delivery. Any such complaints or claims do not discharge the customer of that obligation to pay within the period stated in the conditions of sale. If it appears that a claim or complaint is well-founded, Camida shall make this known to the customer and take the goods back and replace these goods by similar goods or credit the customer with an amount not exceeding the invoice value, without being bound to pay any other damages. Goods may only be returned with the express permission of Camida. 4. If one or more of the factors upon which the cost price was based undergoes an increase, even if this occurs because of foreseeable circumstances, Camida has the right to increase the agreed price accordingly. Goods are at the customers risk from the moment they leave Camida. 5. Title to the goods shall not pass to the customer until all demands have been completely met. In case of late payment, all delivered goods may be claimed by Camida without prior summons and/or notification. 6. Payment must be made not later than 30 days after the invoice date. After the due date, Camida shall be entitled to charge interest at the rate of 2% per month calculated from the invoice date of the outstanding amount. Camida shall have no obligation to make further deliveries as long as the customer remains in default of payment. 7. Where the customer cancels an order, Camida shall be entitled to charge to the customer the entire amount of the relevant invoice (without any obligation to prove damages), plus any additional expenses that may be incurred by Camida as a result of the cancellation, such as transportation, storage or destruction costs in relation to the goods ordered. 8. Failure by Camida to charge interest pursuant to clause 6 above or to make a charge in relation to a cancelled order pursuant to clause 7 or to exercise any of its other rights under this agreement shall not constitute a waiver by Camida of those rights and Camida shall at all times at its own discretion be entitled to exercise in full all its rights hereunder against the customer. 9. The customer acknowledges that Camida acts as a broker only and not as an importer. The customer agrees that for the purposes of all laws or regulations for the time being in force, and for all other purposes, the customer is the importer of the goods and accepts full responsibility for all liabilities that may arise from the importation of the goods and the customer shall hold Camida harmless and keep Camida indemnified in respect of all such liabilities. 10. Where Camida is purchasing goods, the vendor shall keep Camida indemnified and hold Camida harmless in respect of all proceedings, costs or claims arising either by reason of the failure of the vendor to honour its terms of quotation to Camida or arising by reason of any alleged defect in the goods or any allegation that the goods were not fit for the purposes for which they were sold, or otherwise arising by reason of the sale of the goods to Camida or the onward sale of same to third parties, including any costs or expenses (including managerial or administrative time required to be spent on the matter by Camida staff or management) incurred by Camida in defending the proceedings and shall afford Camida all assistance required by Camida or its legal advisors in defending such proceedings. Alternatively, the vendor shall, at the request of Camida and at the sole discretion of Camida take over the defence of the proceedings on behalf of Camida having first provided Camida with an indemnity to its satisfaction, together with such security as Camida considers reasonable to cover any likely liability that Camida may have as a result of such proceedings.

Issue 20

2001/22/11

NEW NAME, SAME PEOPLE Picture the scene - almost midnight in a remote corner of the South West of Ireland. Messrs. Anchell, Bromage, Healy and Hughes had already been musing over a new name for four hours. The task was to find a new name for the MDA & ACI Group that did not insult anybody in far flung corners of the world, but that also had a more international feel than Green Gates Chemicals or Skibbereen Technology! In desperation (and with the pragmatism of an accountant!), Bromage suggested cutting up the letters of MDA and ACI, and tossing them into a hat. The letters were then extracted one by one, in true lottery style. Amid great excitement, the CAMIDA name came into being! CAMIDA was the name given to the Group's holding company. The CAMIDA name has been slowly drip fed into the market place over the last few months, and this process will be accelerated over the second half of this year. The Group exhibited for the first time under the CAMIDA banner at Chemspec, Basel, Switzerland in late June. By the turn of the century on 31 December 1999, the intention is that the ACI and MDA names will finally disappear, and CAMIDA will emerge as a new global force (see article on page 2). The structure and location of the operating companies will remain the same. It is likely that other CAMIDA companies will appear during the year 2000; more details will follow shortly. In the meantime, to all our customers and suppliers, please rest assured that the individual operating companies will provide the same level of service that the market has come to expect from the ACI and MDA companies. It's about time we had another female editor: the men were trying to take over, again! I would like to begin by offering a very warm welcome to my overseas customers in particular, and for those of you whom I have yet to meet, you can now put a face to the name! ADDING THE BALANCE OF A FEMALE EDITOR FROM MDA UK As usual, the few months since our last CAMIDA publication have been hectic, verging on the chaotic! CAMIDA personnel, myself included, have been jetting around the globe trying to keep up with our long-standing customers, as well as tracking down new business from those of you out there who have yet to succumb to the CAMIDA charms: you can run but you can't hide forever! I have visited a number of customers in France, accompanied by our agent, Jean Hine of Ugarit. Meanwhile Allan Hughes and Tom Kelly have been establishing new contacts in Puerto Rico. By the time you receive this issue, we will have exhibited at Chemspec in Basel, under the name of CAMIDA (see article above). Closer to home, CAMIDA personnel have been as active as ever, visiting local customers and continuing to update their skills through training courses. Donald McDonagh and Denis Monahan have been targeting new customers for the Group's food ingredients division. Meanwhile, at MDA UK, Vicki Shakespeare, Meg Wiseman and Emma King have all attended various courses to sharpen their already extensive skills. MDA Americas has a new staff member, Kiersten Weber. Kiersten will be responsible for all aspects of sales administration for our US-based company); welcome aboard, Kiersten! At ACI, we are delighted to have Carly McLoughlin back, after her recent maternity leave. Inter-company visits have also continued, strengthening the bonds within the CAMIDA Group. We also intend to strengthen the bonds that we have with our customer base, and as this base broadens, we hope to establish a solid foundation with new clients as well. I hope this issue of the CAMIDA Review is of interest to you all, and we welcome your enquiries. Here's wishing each of you success in all your ventures this coming year. KIERSTEN WEBER HAS RECENTLY JOINED MDA AMERICAS AS OFFICE ADMINISTRATOR. Kiersten holds a BSc Degree in Exercise Science and Physiology. She has studied at New York University & Rutgers University-Douglass College. Kiersten has worked in various full & part-time positions, ranging from office management to Director of Fitness & Training. She is a Certified Personal Trainer. Born and raised in the New York area, Kiersten enjoys the NYC scene, as well as working out at the gym, tennis, inline roller blading, soccer, and most outdoor sports. E-mail: kiki@mda-americas.com NEW SOURCE FOR DIMETHYL SULPHOXIDE CAMIDA can now offer DMSO from a source not previously available in the European market place. There are several grades available starting with a high purity pharmaceutical synthesis grade, and at the other end of the spectrum, a technical grade used in industrial formulations, e.g. paint strippers. Material is available in bulk ISO tanks with typically a six-week lead time or alternatively, in drums from European stock. We welcome your enquiries for any quantity. Specifications, samples and prices are available on request. PRODUCTS NEW TO OUR RANGE INCLUDE: l 1,2,4,5-Benzene tetracarboxylic dianhydride Butyl levulinate l 5-Chloro-2-mercaptobenzoxazole 7-Chloro-2-mercaptobenzoxazole (development) l 5-Chloro-2-methylbenzoxazole 3-Chloromethyl pyridine cis-2,6-Dimethyl piperazine l Cyanogen bromide Cyanogen bromide - 3M solution in dichloromethane l Dichlorophenylphosphine 3,4-Dimethoxybenzoic acid Ethyl levulinate l 3-Ethyl-1-methyl-2-thiohydantoin 6-Fluoro-2-aminobenzothiazole (development) l 6-Fluoro-2-methylbenzoxazole (development) 1-Hydroxybenzotriazole anhydrous l Indole-3-propionic acid Isophthaloyl chloride Levulinic acid 2-Methyl piperazine l p-Nitrobenzyl bromide 4-Nitrophenyl chloroformate R-Phenyl glycinol S-Phenyl glycinol Phenylsulphonyl azetidinone Phenylsulphonyl cyanide (development) l o-Phthaldehyde Phthaloyl dichloride Pyridinium chlorochromate Sulpholane l 2-Thiohydantoin 4-Tolyl acetic acid 2,2,2-Trichloroethyl chloroformate l 2,2,2-Trichloroethanol 1,3,5-Trimethylbenzene Vanadyl acetyl acetonate STOCK LIST The following items are available ex stock (sub unsold), and we look forward to your enquiries. b 555-62-3 Acesulfame K b 75-05-8 Acetonitrile b 123-54-6 Acetylacetone b 98-16-8 3-Aminobenzotrifluoride b 919-30-2 3-Aminopropyltriethoxysilane b 50-81-7 Ascorbic acid b 17194-00-2 Barium hydroxide b 328-74-5 3,5-Bis(trifluoromethyl)aniline b 7726-95-6 Bromine b 128-08-5 n-Bromosuccinimide b 5743-47-5 Calcium lactate pentahydrate b 79-04-9 Chloro acetylchloride b 870-24-6 2-Chloroethylamine HCl b 4897-25-0 5-Chloro-1-methyl-4-nitroimidazole b 372-09-8 Cyanoacetic acid b 765-30-0 Cyclopropylamine b 105-53-3 Diethyl malonate b 77-76-9 2,2-Dimethoxypropane b 57-48-7 Fructofin C b 106-89-8 Epichlorohydrin b 5470-11-1 Hydroxylamine HCl b 7439-95-4 Magnesium turnings b 2530-85-0 3-Methacryloxypropyltrimethoxysilane b 105-34-0 Methyl cyanoacetate b 144-62-7 Oxalic acid b 865-47-4 Potassium-t-butoxide b 24634-61-5 Potassium sorbate b 89-32-7 Pyromellitic dianhydride (micronised) b 532-32-1 Sodium benzoate b 16940-66-2 Sodium borohydride b 7647-15-6 Sodium bromide b 124-41-4 Sodium methoxide (21% solution) b 124-41-4 Sodium methoxide (30% solution) b 110-44-1 Sorbic acid b Starter distillate 15X b 109-99-9 Tetrahydrofuran b 546-68-9 Tetraisopropyl titanate b 5593-70-4 Tetra-n-butyl titanate b 7719-09-7 Thionyl chloride b 17501-79-0 Titanium acetylacetonate (67% solution) b 17501-79-0 Titanium acetylacetonate (75% solution) b 99-04-7 m-Toluic acid b 99-94-5 p-Toluic acid b 96-18-4 1,2,3-Trichloropropane b 102-24-9 Trimethoxyboroxin b 149-73-5 Trimethyl orthoformate b 17501-44-9 Zirconium acetylacetonate b 1071-76-7 Zirconium n-butoxide

Issue 21

2001/22/11

Pre-millennium comment from the Americas. As we approach the millennium, CAMIDA and its operating divisions are on schedule with a five-year strategic plan. The direction and forward growth of the CAMIDA Group is both ambitious and exciting, Reflecting the Group's continued growth and strength, all operating companies - MDA Continental NV, ACI Ltd, PHARMALINE srl, MDA Chemicals Ltd, and MDA Americas LLC - will be renamed 'CAMIDA' with effect from 1st January 2000. As noted in the last issue, the name 'CAMIDA' is not an acronym, but is the rearrangement of the names of the founding companies, ACI and MDA. In late August, we launched our website under the name www.camida.com to provide a fast, accurate flow of information to our current and potential customer base. Our website provides access to valuable product and company data with a simple ""point and click"", (see article on page 2). CAMIDA differentiates itself as a pure sourcing company through its expertise and knowledge of current product and manufacturing on a global basis. Thanks to its brilliant worldwide network, CAMIDA has contacts with colleagues across the globe, including the most exotic and/or remote countries. As part of the CAMIDA Group, UK-based SynProTec provides on-demand expertise in contract research, kilo-lab activities, as well as fine chemical manufacturing from gramme to multi-tonne quantities. Through the support of SynProTec's staff of chemical engineers and scientists, CAMIDA can bring higher value in a more timely fashion to our customers, thus meeting and often exceeding the demands of our customers. Finally, as part of the CAMIDA Group, MDA Americas has been operating in the Americas since 1996. MDA Americas has stepped forward with a much more aggressive sales campaign to insure maximum coverage of both strategic and non-strategic businesses. Like all other operating divisions of CAMIDA, MDA Americas is committed to Responsible Care and the flawless execution of all programmes. These are clearly exciting times for CAMIDA and we invite you to visit our website for details and information on CAMIDA's rapidly expanding organisation. CAMIDA's development and manufacturing arm SynProTec Ltd, based in Manchester, England, acts as the development and manufacturing partner of the CAMIDA Group. Independent but with CAMIDA as stakeholders since 1997, SynProTec has steadily expanded since its formation in the early 1980s. A recent major investment programme has built and maintained the company's reputation as a world class research and development company. A key strength is the company's investment in quality personnel. More than 40% of SynProTec's people have science degrees and more than 30% have a second degree. Staff turnover is very low, ensuring continuity for the client. With major investment in large scale equipment now fully operational, SynProTec can offer clients a range of vessels from 20 litre to 6,500 litre. Thus, it is one of the very few companies that can offer gramme to tonne quantities via three business areas: Contract Development Development services can range from offering a "one-off" synthesis of a novel molecule to the establishment of a full scale manufacturing process for pharmaceutical, agrochemical or fine chemicals. Clients obtain the same quality service for a month's work, as for an extended project. The company's client list speaks for itself. Confidentiality is paramount, and although SynProTec is happy to offer a client list (with the client's permission!), all technical and commercial details of projects are strictly confidential. The programme is proposed following detailed meetings to establish the ""deliverables"" for the client. This outlines how the work will progress, how it will be managed, who will manage it, and very important, the time it will take. All this is submitted to the client as ""the proposal"", which will also be subject to a fixed price for the duration of the work. Intellectual property will belong to the client! If during the life of the project a number of novel, even patentable routes and processes are developed. These will be the property of the client, not of SynProTec. SynProTec can offer world class expertise in certain areas for industrial clients. These include: Halogenation Organometallic & Grignard Chemistry Nitration Ozonolysis Electrochemistry Vapour Phase Catalysis Hydrogenation. They can also offer expertise on the use and application of loop reactors. Kilo and Pilot Plant Facilities As a natural development of work carried out on bench scale, many satisfied clients ask for the work successfully completed to be scaled up to multi kilo amounts. This could be from 1000gm to 200kg. completed to be scaled up to multi kilo amounts. This could be from 1000gm to 200kg. SynProTec's facilities to carry out these are available from 35 litre to 125 litre. Both glass lined and stainless steel vessels are available. Temperature ranges in this facility are wide ranging from a cryogenic unit offering -100oC to hot oil at 260oC. All plant is flameproof, multi-purpose and designed to be readily modified to handle a wide range of reaction conditions. Distillation facilities are available including short path (wiped film) and fractionation with up to 100 plates. With the increase in pharmaceutical products being outsourced, SynProTec has a laboratory that is dedicated to companies requiring a cGMP facility. This will be enhanced with the addition of a pilot plant, which is in the early stages of construction. Both facilities will satisfy the requirements of cGMP in both practical operation and in the data recording requirements that cGMP demands. Fine Chemical Manufacturing Fine chemical manufacture, for a wide range of industrial clients, offers both final products and intermediates. Staffed with high calibre, qualified personnel, the plant is designed for the safe handling of a wide range of hazardous materials Vessels available include glass-lined to 6,500 litre and stainless steel to 3,000 litre. All reactors are multi-purpose and vessel overheads can be changed quite readily. We can offer temperature ranges from -45oC to 170oC, vacuum to 1mb. Solids isolation equipment includes centrifuges, vacuum and pressure filters. Vacuum, tray and paddle dryers are available. In addition to contract manufacturing services offered to clients, SynProTec also manufactures a range of fine chemicals which include: 3,5-bis(trifluoromethyl) benzylbromide. 3.5-bis (trifluoromethyl) benzoic acid. 3,5-bis (trifluoromethyl) benzoylchloride. 3,5-bis (trifluoromethyl) nitrobenzene. 3,5-bis (trifluoromethyl) acetophenone. 3,5-bis (trifluoromethyl) benzaldehyde. Methylenedioxybenzene derivatives Chiral nematic liquid crystals. Quality assurance is vital to the efficient operation of a chemical manufacturing company and the company recognises that its analytical and quality control must be first rate in order to support its fine chemical manufacturing operations, laboratory and pilot plant functions. Analytical facilities are comprehensive and include GC-mass spectrometry, NMR, FTIR spectroscopy, Atomic Absorption, GC and HPLC. South Africa's largest exporter Next Chimica, a Johannesburg-based company, specialises in the manufacture of precious metal chemicals and the refining of precious metals. Over the past ten years, the company has developed the necessary in-house skills and expertise to manufacture chemicals of the precious metals. Next Chimica is now well-placed in the highly-competitive and specialised international market for these products. Although precious metals have been produced in South Africa since the late-nineteenth century, there has been considerably less downstream development of industry. Instead, most of the refined metals have historically been sold on the international precious metals market, generating a major proportion of South Africa's foreign revenue. Among all the elements in the Periodic Table, precious metals, and specifically the platinum group metals (platinum, palladium, rhodium, ruthenium, iridium and osmium), have unique properties. These include the metals' resistance to chemical corrosion and oxidation, and their catalytic properties. These properties are exploited in the industrial applications of the precious metals, which include areas such as electroplating, electronics, mirrors, autocatalysts, cancer-treatment drugs and catalysts in the petrochemical industry. Industrial applications of the precious metals often require the metals in chemical form as a raw material, rather than in a metallic form. Here, the very properties that are exploited in the industrial applications of the precious metals sometimes make it difficult to convert the metals from the metallic form to precious metal chemicals. Next Chimica routinely manufactures some 43 of the most important precious metal chemicals, and has the further capability to supply a wider range of specialised precious metal chemicals on a custom-manufactured basis against specific customer requirements. The company supplies its products to customers within South Africa, and is the largest South African exporter of precious metal chemicals, routinely exporting products to customers in more than 17 countries. Although Next Chimica has established itself as a reliable supplier of high-quality products, the company still faces the daily challenge of competing in a highly-specialised and competitive global market. ""With the increasing globalisation of markets, we believe it is no longer sufficient to undertake operations or be competitive in line with local requirements and standards only, says Next Chimica managing director, Dr Mick Albers. ""To sell our products in Europe, we have to comply with the same requirements placed on European manufacturers, and thus compete with them on an equal footing. The same is true of all other international markets. This means that, as a manufacturer who intends to compete globally, we must be geared to comply with the most stringent requirements applicable to our industry anywhere in the world, as well as to satisfy every requirement of our customers. "At Next Chimica", he says, "this challenge is addressed by continually pursuing and achieving excellence in all aspects of the business, especially through technical innovation and development, and a focus on continuous improvement and quality." The company recently completed the development and installation of its quality management systems. The quality management system was certified by DQS German Association of Certification of Management Systems to comply with the requirements of the International Standard ISO 9002, Quality System Requirements QS 9000 and VDA 6.1. According to Roy Norrie, group quality assurance manager at Next Chimica, the company's objective was "to develop and install a quality management system which complied with the appropriate international standards, and which could be benchmarked within the industry." Says Albers: "The role of the quality management system in the operation of a business has undergone radical evolution in recent years. It is no longer simply an adjunct to a company's management system and activities, but is now a fundamental component of every aspect of a company's operations. The definition of quality has broadened holistically to include aspects such as pricing, delivery performance, responsiveness of the supplier to customers' concerns and requirements, and continuity of supply." This new definition of quality is not just the result of a manufacturing operation or a "traditional quality control" operation, but is the product of an integrated business operation, including strategic business planning, personnel management, supplier development, logistics, operations management, quality planning and management and production management. Part of Next Chimica's strategy is the dynamic capability to address and exceed customers' requirements. "As the products we manufacture are used as raw materials in high-technology industries, it is vital to have the expertise and vision to foresee and address the concerns and requirements of our customers, and to make it easier for clients to do business with us", says Dr Albers. Contact your local CAMIDA office for further information on Next Chimica's products. Next Chimica: Products at a glance Platinum Platinum sponge Pt Hexachloro platinic acid H2PtCl6.8H2O Hexachloro platinic acid solution in hydrochloric acid H2PtCl6.solution Potassium hexachloro platinate K2PtCl6 Potassium tetrachloro platinate K2PtCl4 Tetraamine platinium (II) nitrate [PT(NH3)4](NO3)2 Tetraamine platinium (II) nitrate solution [PT(NH3)4](NO3)2 solution Platinum (IV) oxide hydrate PtO,XH,O Palladium Palladium sponge Pd Palladium (II) chloride PdCl2.xH2C trans-Diammine dichloro palladium trans-Pd(NH3)2Cl2 Palladium (II) nitrate solution in nitric acid Pd(N)3)2.solution Tetraammine palladium (II) chloride [Pd(NH3)4]Cl2 Palladium acetate PJ(CH3CO2)2 Rhodium Rhodium sponge Rh Rhodium (III) chloride hydrate RhCl3.xH2O Rhodium (III) chloride solution in hydrochloric acid RhCl3.solution Rhodium (III) iodide RhI3 Rhodium (III) nitrate solution in nitric acid Rh(NO3)s solution Iridium Iridium sponge Ir Hexachloro iridic acid H2IrCl6.xH2O Hexachloro irdic acid solution in hydrochloric acid H2IrCl6.solution Iridium (III) chloride hydrate IrCl3.xH2O Ruthenium Ruthenium sponge Ru Ruthenium (III) chloride hydrate RuCl3.xH2O Ruthenium (III) chloride solution in hydrochloric acid RuCl3 solution Osmium Osmium sponge Os Osmium tetraoxide solution in water OsO4 solution Osmium tetraoxide OsO4 Potassium osmate K2OsO4.2H2O Osmium (III) chloride hydrate OsCl2.xH2O Potassium hexachloroosmate K2OsCl5 Ammonium hexachloroosmate (NH4)2OsCl5 Osmium powder < 60 micron particle size Os Sodium hexachloroosmate Na2OsCl6 Silver Silver granules Ag Silver nitrate AgNo3 Silver sulphate Ag2So4 Silver chloride AgCl Silver cyanide AgCN Silver potassium cyanide KAg(CN)2 Silver (I) oxide Ag2O Gold Gold granules Au Tetrachloroauric acid hydrateHAUCL4.xH2O Gold potassium cyanide KAu(CN)2 Tetrachloroauric acid hydrate brown HAuCl4.xH2O Tetrachloroauric acid solution HAuCl4.solution CAMIDA sponsors UK under-15 cricket champions To those readers outside England, the game of cricket probably seems a complete mystery, although the former British Commonwealth countries seem to have got much better at the game, than the originators! CAMIDA recently sponsored the 'under 15' Lancaster Royal Grammar School cricket team, who were recently successful in becoming national United Kingdom champions at this age level. This was seen as a tremendous achievement by Lancaster, with the competition being held over a period of two years, and 1,800 teams initially entering the competition. The thrilling and tense final took place at Trent Bridge, Nottingham, one of the famous test cricket grounds in the UK. CAMIDA is pleased to be associated with this team, and hope that Lancaster Royal Grammar School go on to greater success in the future! CAMIDA launches website CAMIDA is pleased to announce the launch of a group website: http://www.camida.com. The website ensures CAMIDA's continuing presence at the cutting edge of industry. Although the SynProTec website will continue to function as before, the CAMIDA site will now function as the sole group website. On typing ""www.camida.com"" into the address bar of your Internet browser, you arrive at the site's "front page". From here, you may access short pieces on CAMIDA in terms of group profile and markets, and also on our special capabilities for sourcing, research & development, and global networking with our INDIS associates. There is also a statement on our quality commitments and a listing of our product range. At the bottom of the front page are several buttons linking users to other areas of the site. The first button is a link to a page where you can make contact with the appropriate CAMIDA person via e-mail. You simply select the country in which you are based, and the text you type into the box will be sent to the person responsible for your country. This provides an easy way to make contact with a person you know can help you. The second button is a link to an animated corporate presentation, intended to give an overview of the CAMIDA Group. The third button links to an area of the site dedicated to an on-line version of this quarterly newsletter, allowing you to subscribe in e-mail form. The final button leads to a "links page" where you can access the web-sites of appropriate companies and organizations. Glossary Address Bar: The blank input area of your Internet browser just below the navigational buttons. Internet Browser: The software used to view Internet sites, e.g. Microsoft Internet Explorer, Netscape. Front Page: The first page you see when you open a website. Buttons: An area of the page that reacts when clicked with the mouse. e-mail: literally ""electronic mail"". On-line: Meaning available on the Internet (as opposed to a hard copy on paper). Links Page: A page with a list of related websites, which you can access by clicking with the mouse. (The CAMIDA website was designed by David Kane of Hegarty Computer Services, ACI's computer consultants. The project was co-ordinated by Tom Anchell of ACI Ltd) New intermediates The following intermediates are now available: 4-Hydroxybenzyl alcohol - Sinochem JY N-Phenylthiourea - Sinochem JY 2-Aminobenzothiazole - Sinochem Hebei 2-Thiophenecarboxylic acid - Sinochem JY Also we have a new source for: 2-Hydroxyisobutyric acid, and its esters; Esters include the methyl and ethyl, from stock, with the n-propyl, isopropyl, butyl and 2-ethylhexyl available on special order. Please contact your local CAMIDA office for further information. Papain: new supply source ACI has an excellent new supply source for Papain. Papain is a food grade proteolytic enzyme isolated from the latex of the Carica papaya fruit. Papain hydrolyses most common proteins, i.e. gelatin, casein, fish, soya, etc. The protease exhibits a broad pH and temperature tolerance and degrades protein more extensively than other proteases, giving rise in many cases to free amino acids. Applications Brewing: Chillproofing of beer Fermentation: Hydrolysis of protein fermentaion media Fish: Processing of fish soluble and whole fish Meat: Tenderisation of meat Soya: Processing soluble and hydrolysed proteins Feed supplement: To improve animal feed utilisation and efficiencies Leather: Bating of hides Pharmaceutical: Digestive aids and debridement. Please contact ACI Ltd with further enquiries. ACI has new source for potato starch ACI has now developed an exclusive supply arrangement for Ireland with Sudstarke Germany. Established in 1938, Sudstarke is one of Europe's major potato starch manufacturers. Sudstarke's range includes native potato starch, pregelatinised starch, modified products and many other specialities. Potato starch has many applications in the bakery, meat, dairy and processed foods sectors. Native starch is used extensively in soups and sauces. Sudstarke's special low moisture potato starch is used as a thickener and moisture stablisier in dry mixes. Specialities like Aero-Myl 33 is a special low bulk density, pregelatinised starch that is used to improve flow properties and as a volume extender for instance products. Alimentamyl AC 2310 is an acidstable modified starch used in frozen and tinned food and milk products. A range of freeze / thaw stable starches for the bakery industry is also available. For more information, contact Denis Monahan at ACI Ltd., (denis@aci.ie).

News

2001/22/11

New US Office We are very pleased to announce the opening of CAMIDA LLC, our USA sales office, in the Gateway Centre, Newark, NJ. We look forward to serving our customers in the East Coast area, and also to taking advantage of our proximity to Newark International Airport. As Newark Airport is a major stopover point for onward travel, we have already found it convenient to meet some of our customers passing through. The US sales office staff will consist of Allan Hughes and Kevin Dalton. Kevin joins CAMIDA LLC as Sales Manager. Kevin is a graduate of University College Cork, Ireland, where he obtained a Masters Degree in Biochemistry. He previously worked with Schering-Plough & Warner-Lambert in Cork, and most recently worked as Sales Manager with Healy Chemicals in Dublin. With Healy Chemicals, he concentrated mainly on the supply of excipients and active ingredients to the pharmaceutical industry. Kevin is now enjoying the fun of NYC from his home base in Hoboken, NJ. As a keen sports fan, he is already supporting the colours of the NY Mets and NY Giants, but still finds time to kick a soccer ball with the local Hoboken soccer team. Kevin was pleased to meet some friends in the recent SOCMA dinner held in the Marriot Marquis Hotel in NY and looks forward to making more friends and customers in the US in the near future. New Intermediates - Now Available Imidazole - a new source! Para-benzoquinone - a new source! 2-Amino-5-chlorobenzonitrile Sodium amide - a new source! Ferrous calcium citrate N-methylpyrrolidone - a new source! Benzyl Alcohol, Benzyl Chloride - new group of products for INDIS/CAMIDA Arising from CAMIDA's involvement in INDIS during 1999, we can now offer CAMIDA-branded Benzyl Alcohol and Benzyl Chloride. The CAMIDA group now has a dedicated product manager to look after this business. Due to the combined purchasing power that the INDIS group has around the globe, we can offer top quality production at competitive pricing. INDIS has contracted CAMIDA's annual requirements to a world class European producer of this product, who has committed to helping us market their products worldwide. ""It really is a 'win win' situation all round,"" said David Anchell, Managing Director of CAMIDA Ireland. ""We can ensure our customers get a competitive supply of quality product and the manufacturer is assured of extensive market penetration from the INDIS members."" Benzyl Alcohol, pure grade (Assay 99.8%) has many applications, namely: Coatings and Auxiliaries. Disinfectants and cleaning agents. Glues and Adhesives. Cosmetics and Auxiliaries. Perfumes and Aromas. Active Substances and Auxiliaries for Pharmaceuticals. Standard packing: Stainless steel road tanker, or 210 kilo rolling channel drum. For further details contact Donald at CAMIDA (donald@camida.ie) or tel +353 52 25455. Congratulations to Deirdre McGrath of CAMIDA in Ireland Deirdre recently responded positively to a request from Eamonn (a.k.a ""The Lemsip Kid"") for her hand in marriage! On the left is a sneak shot of the handsome couple on the occasion of the public proposal!

Stock List

2001/22/11

The following items are available ex-stock, sub unsold, and we look forward to your enquiries. 555-62-3 Acesulfame K 75-05-8 Acetonitrile 123-54-6 Acetylacetone 98-16-8 3-Aminobenzotrifluoride 919-30-2 3-Aminopropyltriethoxysilane 50-81-7 Ascorbic acid 17197-00-2 Barium hydroxide 328-74-5 3,5-Bis(trifluoromethyl)aniline 7726-95-6 Bromine 1081-73-8 1-[2-(4-Bromophenoxy)ethyl]pyrrolidine 128-08-5 N-Bromosuccinimide 5743-47-5 Calcium lactate pentahydrate 79-04-9 Chloroacetyl chloride 870-24-6 2-Chloroethylamine HCl 372-09-8 Cyanoacetic acid 105-53-3 Diethyl malonate 77-76-9 2,2-Dimethoxypropane 57-48-7 Fructofin C 106-89-8 Epichlorohydrin 51934-41-9 Ethyl-4-iodobenzoate 5470-11-1 Hydroxylamine HCl 7439-95-4 Magnesium turnings 2530-85-0 3-Methacryloxypropyltrimethoxysilane 105-34-0 Methyl cyanoacetate 144-62-7 Oxalic acid 865-47-4 Potassium-t-butoxide 24634-61-5 Potassium sorbate 89-32-7 Pyromellitic dianhydride (micronised) 532-32-1 Sodium benzoate 16940-66-2 Sodium borohydride 7647-15-6 Sodium bromide 124-41-4 Sodium methoxide (21% solution) 124-41-4 Sodium methoxide (30% solution) 110-44-1 Sorbic acid Starter distillate 15X 109-99-9 Tetrahydrofuran 546-68-9 Tetraisopropyl titanate 5593-70-4 Tetra-n-butyl titanate 7719-09-7 Thionyl chloride 17501-79-0 Titanium acetylacetonate (67% solution) 17501-79-0 Titanium acetylacetonate (75% solution) 99-04-7 m-Toluic acid 99-94-5 p-Toluic acid 96-18-4 1,2,3-Trichloropropane 102-24-9 Trimethoxyboroxin 149-73-5 Trimethyl orthoformate 17501-44-9 Zirconium acetylacetonate 1071-76-7 Zirconium n-butoxide thin

Features

2001/22/11

INDIS Associates meet in Germany David Anchell represented the CAMIDA Group at this year's INDIS meeting. The most recent meeting of INDIS associates worldwide was hosted in Cologne by the 1999 INDIS president, Bernd Barthels of Galvachem GmbH, INDIS's German member. INDIS stands for International Distribution. INDIS membership is comprised of about 25 specialised chemical trading companies throughout the world who work together to foster trade between each other and who also share common principles and objectives. The association was founded in 1998. There is only one member of INDIS for each country. Total group sales reached USD130 million in 1998, and are forecast to reach over USD 2000 million in 2000. CAMIDA is a founder member of INDIS. Membership of INDIS gives CAMIDA global reach into overseas territories. We are able to use other members as a sourcing agent or as a local contact to resolve any difficulties of supply to pre-audit manufacturing sites and to ensure all our quality aspirations are fulfilled. In addition to the annual conference, there are regular meetings and daily contact among members. This year's conference was held during the last week of October and it was the most comprehensive programme to date. In addition to discussions among the group, we enjoyed presentations from many business contacts from the German Industry. Bernd arranged a broad range of social activities in and around Cologne to complement the long business days! We were pleased to welcome a new INDIS member, Mr Henry Cha of Changje Trading Co Ltd in Seoul, Korea. Korea is an important country for pharmaceutical and specialised chemical production and we are delighted to have a partner to work with on the ground there. Mr Rex Gorden of Tiger Chemicals, Australia was elected president of INDIS for 2000. Rex is the first past president to be re-elected for a second term. He has decided for variety and to add business substance to hold the next meeting of INDIS Associates in Taiwan. He will there enlist the support and assistance of our Taiwanese member, Mr. Jey Tsai of Daopoly. We look forward to another year of international co-operation and to meeting again next year in Taiwan. Fromatech Ingredients joins Forces with CAMIDA to offer endless Flavour Possibilities CAMIDA became the exclusive agent in Ireland of Fromatech Ingredients in September 1999. Based in Holland, Fromatech is widely regarded as one of Europe's most innovative, but still very competitive, flavour manufacturers. CAMIDA has already found that the reaction of many customers in Ireland has been extremely positive. Fromatech is willing to work with customers in a very transparent way to ensure they get the flavour they want at a price that suits. This flexibility is a major advantage of using Fromatech for product development, and ongoing product improvement work. The co-operation between CAMIDA and Fromatech will offer the Irish market ingredients designed for use as a complete seasoning in a final product, or single functional ingredients that can be combined with other ingredients to create a unique recipe. Fromatech flavours are typically included in products such as dry blends, sauces, gravies, soups, canned meats, confectionery, chocolate, pizza/pies/processed meats, yoghurt and flavoured milks, ice cream and soft drinks. Fromatech traces its origins to the cheese business, with the company's Managing Director, Peter Nielsen, having purchased many thousands of tonnes of Irish cheese over the years. Cheese flavours are now Fromatech's major line, with many thousands of taste profiles on offer. All flavours are available - from cheddar, to camembert, to parmesan, etc. Savoury flavours supplied include bacon, ham, beef, chicken, and variations thereof. These are used typically in seasonings, for injection brines, or individually added. Also popular for the processed meats sector are flavours that complement the taste of meat, such as honey, apple/cinnamon, garlic, smoke, etc. Fromatech also has great expertise in the dairy flavours sector, such as butter, cream and yoghurt. Those looking for mint, mustard, tarragon or any of hundreds of the available vegetable flavours available will also be very impressed by the quality and the pricing offered by Fromatech. Additionally, a full range of sweet flavours is available on request. Amongst the more unusual ingredients on offer are a tangy yoghurt flavour for a salad dressing or a honey powder for a nutraceutical applications. Fromatech can offer GMO-, HVP- and MSG-free products to suit customers' needs. Most flavours are available in liquid or in powder form and can be produced to any customer specification. Fromatech's ability to provide alternatives for existing flavours is very impressive. CAMIDA can verify that when customers are willing to work with Fromatech they will be able to achieve any desired flavouring within a predetermined price range. We welcome anyone with flavour requirements to contact Donald McDonagh at CAMIDA (donald@camida.ie). Central Soya Stern Exclusive for CAMIDA CAMIDA is pleased to announce the recent signing of an exclusive distributor agreement, within Ireland, with Central Soya Stern, one of the world's leading suppliers of lecithins. Central Soya Stern is headquartered in the USA and has fractionation and refining facilities throughout Europe. Like CAMIDA, the company is ISO-certified and is committed to permanent quality assurance. ""This is a very important opportunity for CAMIDA, as it is a good strategic fit with our plans to broaden our Food Ingredients division"", said CAMIDA's Donald McDonagh. Lecithin is made of natural phospholipids that occur in nearly all the cells of living organisms. Although lecithin takes its name from the Greek word for egg-yolk (Lekithos) it is now extracted mainly from soybeans. Crude lecithins - 0.5-0.6% of the soybean - are by products of soya oil production. Being natural substances, they show great variations in their functionality, structure and composition. This means that lecithins have greatly different properties according to the extraction methods used and their particular phospholipid composition. Central Soya Stern offers a broad product range of active and modified, deoiled and powdered, hydrolysed and acetylated lecithins. In their modern lecithin plants in Rotterdam, Cologne and the USA, crude lecithins are treated and modified to become effective emulsifiers, and dispersing and wetting agents. The secret of the surface activity of the lecithins lies in the fact that they are amphiphilic (ie contain both ""water repellant"" and ""water friendly"" parts) and thus stabilise both O/W and W/O emulsions. Applications: Standardised and modified Central Soya Stern lecithins are indispensable ingredients in the food industry. They give important functional properties to foods such as milk powders, dairy products and spreads, chocolate, instant products, baby food, bread and other bakery products, releasing agents, chewing gum and fat substitutes. From a labelling perspective, lecithins have a good reputation in the eyes of the consumer, being a natural emulsifier, and having health-giving nutrient substances that are proven to be beneficial to the liver, kidneys and other tissues of the human body. CAMIDA and Central Soya Stern would be happy to answer enquiries from industry as to suitable lecithins for unique applications. For further information, contact Donald McDonagh at CAMIDA, (donald@camida.ie). Organosilicon compounds & Silylating agents for Organic Synthesis The use of organosilicon compounds in organic chemistry has grown in importance in recent times. Shin-Etsu Chemical Company supplies several kinds of silylating agents and is constantly seeking new, useful organosilicon compounds in this field. Silylating agents are reagents that replace an active H-species by RR'R""Si-group for certain purposes. For example, -OH,-COOH, -NH2,-CONH2, -SH groups are converted to -OSiRR'R"", -COOSiRR'R"". -NHSiRR'R"", CONHSiRR'R"", -SSiRR'R"" respectively. In general this type of replacement decreases the reactivity of the functional group and reduces polar and hydrogen interactions. The main purposes of silylation is as follows: Protection of reactive functional group during chemical reaction Improvement of reaction selectivity Improvement of stability during distillation Improvement of solubility in polar and/or non-polar solvents Elimination of hydrogen-bonds results in increased volatility Selected silylating agents The silylating agents used on an industrial scale are listed in Table 1. Reactivity, kind of by-product, price and availability are important factors in selecting the synthetic process. The stability of the silylated functional groups is affected by the bulkiness of the R, R', and R"". In general, when the bulkiness of the alkyl group attached silylating agents increases, the stability of silylated functional groups also increases. The stability can be estimated from Taft's parameters (see Table 2). CIPS is a bi-functional silylating agent and is effective in the synthesis of nucleosides such as anti-HIV drugs. The protective groups are easily removed with water or alcohol. Other organosilicon compounds Applications other than silylating agents, such as reducing agents, alkylating agents etc, have increased recently. Thse organosilicon compounds are listed in Table 3. CMTMS, TMA, ATMS and TMVS are used in alkylating reaction or preparation silicon containing organic compounds. TES and HBS are used as reducing agents. PMDS is a precursor of trimethylsilyliodide, which is used in ether and ester bond cleavage reaction under neutral conditions.

Contacts

2001/22/11

Ireland CAMIDA Ltd Tower House New Quay Clonmel Co. Tipperary Ireland Tel +353-52-25455 Fax +353-52-25466 Info@camida.com Managing Director : David Anchell david.anchell@camida.com Sales Director: Orla Heenan orla.heenan@camida.com Group Financial Director : Bernard Pollard bernard.pollard@camida.com Food Ingredients Manager: Richard.Sheehan richard.sheehan@camida.com Co. Secretary/Office Manager: Deirdre McGrath deirdre.mcgrath@camida.com Sourcing Specialists: Lisa Daniels lisa.daniels@camida.com & Yvonne Mullins yvonne.mullins@camida.com Logistic Administrators: Breda O'Dwyer breda.odwyer@camida.com, Catriona Maunsell catriona.mansell@camida.com, Nicola Ward nicola.ward@camida.com, Susan Aherne susan.aherne@camida.com United Kingdom CAMIDA Ltd Willow Mill Caton Lancaster, LA2 9RA United Kingdom Tel +44-1524-771881 Fax +44-1524-771882 Info@camida.com Sales Director: Allan Hughes allan.hughes@camida.com Sales Manager: John Mcneille john.mcneille@camida.com USA CAMIDA LLC One Gateway Centre Suite 2600 Newark, New Jersey 07102 Tel +1-973-645-9227 Fax +1-973-645-9484 Infocamida@cs.com Sales Manager: Kevin Dalton kevin.dalton@camida.com CAMIDA Holdings Ltd Tower House New Quay Clonmel Co. Tipperary Ireland Tel +353-52-25455 Fax +353-52-25466 Info@camida.com

Issue 27

2001/14/12

Adminstration: the backbone of it all! Deirdre McGrath, Manager of Camida's Administration Centre, updates us on the Centre's activities This is probably the first editorial focusing on the administration activities of Camida. This I might add is my 'baby' and, in a work context, the topic I am most comfortable talking about (no chemistry background, here I'm afraid!). Camida's Administration Centre is the hub of all administrative activities from sourcing, to logistics, to financial and general administration. The management of all our departments and territories is now integrated, thanks to implementation of our software package, Chempax. As we had anticipated, Chempax has made life a lot easier for all concerned and allowed us to improve service to our customers, which is always our number one priority. Having acquired a further unit here in Tower House, Clonmel, we have been able to segregate all departments, allowing each to concentrate on their individual roles without interference from colleagues across the room (...... those logistic administrators can certainly get hot tempered when things aren't running smoothly, so its better for all to keep their distance!). Administration projects currently being undertaken include the updating of our website, the fine tuning aspects of our Chempax package, and the revamping of our ISO systems (we are currently rewriting procedures to suit our new Administration Centre). We hope to sit our first audit to acquire the new ISO Standard 9001 accreditation in early January 2002. We have also volunteered to be one of the pilot companies to sit the second phase of the Responsible Care Audits, which will be based on ESAD (European Single Assessment Document). So as you can see, we will be pretty busy over the coming months. From the Administration Centre, we would like to thank all our customers and suppliers for their patience with us while we reorganised the administration function. I assure you all of our continued customer service of the highest standard possible. Contract Chemicals invests at Knowsley While Contract Chemicals has undergone some changes in the recent past, the focus, as ever, remains on the manufacture of high quality fine and speciality intermediates for use in the pharmaceutical, agrochemical, flavours, fragrance and detergent industries. Perhaps the most significant of recent developments has been the continued expansion of facilities at our headquarters site based in Knowsley, UK. Purchased from Tate & Lyle in 1983 the site has traditionally supported both toll and contract manufacturing operations, as well as producing a wide range of ""own products"" across our core technologies of amination, bromination, cyanation, epichlorohydrin, Friedel-Crafts and thionyl chloride chemistry. In 1995 the addition of established bromination technology to our core capabilities introduced brominated intermediates to Contract Chemicals and our customers. With the company boasting expertise in elemental, and free radical bromination, as well as hydrobromination techniques, products offered include an extensive range of bromo- and dibromoalkanes, acyl- and bromoacylbromides as well as bromoacids and their esters. More recently in recognising the importance of chirality in the life science sector, work is also underway to add chiral bromine compounds to our product range. Backing our understanding of the basic chemistry is our commitment to remain at the forefront of plant and process technology. To ensure our position as a strategic global supplier of brominated intermediates we have undertaken a GBP 15 million investment programme, bringing some of the most modern and flexible technology available today to the state-of-the-art Bonner Building at Knowsley. Completion of the first tranche of investment in 1998 saw the installation of a 23,000 litre glass-lined reactor, believed to be the largest of its kind in the world, and a fully contained plant for the production of aromatic-side chain brominated compounds. The latter plant allows the handling of materials that are severe lachrymators, enabling the synthesis of a wide range of substituted benzyl bromides, benzaldehydes and cyanides. Products currently under manufacture, or in late stages of development include 4-bromobenzyl bromide, 4-bromobenzaldehyde and 2-bromophenylacetonitrile. The second phase of capital investment, due to complete early September, will add a further four 12,500 litre glass lined vessels and bring total reactor capacity at Knowsley to in excess of 200,000 litres. When fully operational the 75,000 litres of dedicated bromination capacity will consume in excess of 2,000MT of elemental bromine a year! (Camida is an agent of Contract Chemicals.) Metal Catalyst Technology Metal Catalyst Technology (MCT) constructed a new, state-of-the-art technology catalyst plant during 2000, and completed the commissioning later that year. The plant is now in full operation, producing a range of Raney type catalysts based upon nickel, cobalt and copper, with a variety of metal dopants and process enhancers. The plant is the most modern catalyst plant in the world and is located on the LSM site in Rotherham, South Yorks UK. The plant and process fully satisfy all of the current health, safety and environmental requirements. The process has now been certified to ISO 9001 and Kosher standards. Raney catalysts are used in many different hydrogenation and amination applications, many of which are described on the company's web site: www.metcat.com. A visit to the web site (plant page) will also give an insight to catalyst manufacturing processes and the opportunity to see the installed equipment. Lecithin in Bakery Products Lecithins are indispensable natural additives in the food industry and have a particular role to play in contributing greatly to the quality of finished baked products. The amazing property of surface-active agents such as lecithin is their emulsifying power at low concentrations (0.1 - 0.5%). Volume improvement, fat dispersion and anti-staling properties can be positively influenced by hydrolysed, deoiled and fractionated lecithins respectively. Our principal, Central Soya European Lecithins, are involved in a number of customer projects in their Lecithin Application Centre in Denmark examining the relative performance of lecithins versus monoglycerides and DATEM in a variety of baked products including European pan bread, French brioche, sweet goods (cookies) etc. Extensive literature reports have been published which we will be happy to disseminate on request. Lecithins are based on natural renewable resources and enjoy wide consumer acceptance, based on their twin function as natural emulsifiers and health-giving nutrient substances. They have also a role to play in the increasing drive towards ""green"", organic product connotations. A particularly exciting development at present relates to Central Soya European Lecithin's introduction of new soft seed lecithins, based on rapeseed and sunflower. These have been developed in order to complement the existing IP grades of soya lecithins for those with GMO concerns. Central Soya will be previewing these exciting new products at the upcoming FIE in London on 5th - 7th November. They would be pleased to receive interested parties at their Stand M 70, South Hall. For further information, please contact any Food Ingredients personnel at Camida, or directly: Michael Sponholtz Lecithins Application Manager, Central Soya European Lecithins Tel: +45 89 31 2160 E-mail: msponholtz@dk.cereolworld.com International Sales update John Geraghty, International Sales Manager, lets off steam! Hello to all my customers, and any potential customers that might see this from their international sales desks. This is I hope the first of many updates from me to be included in this newsletter. Things have been very busy since taking over this position in April. I got married in June (see below); I have also managed to visit many of you. I have visited Spain, France, Switzerland, Belgium, Germany, Sweden and Denmark. Although I have endeavoured to see all of you this was not always possible; for those that I have not met so far, hopefully I will catch up with you at CpHI. We are exhibiting at stand F76, South Hall, Area IV, 8-10 October ..... there's nowhere to hide so you may as well give into your urges and use Camida to source your much needed intermediates, or just call in for a glass of champagne! This issue of our newsletter is packed with new products that we can offer. If any of these are of interest to you, or if you are sourcing any other products, please do not hesitate to contact me (john.geraghty@camida.com). New building blocks from Solvay Fluor Solvay Fluor, the world's leaders in trifluoroacetic acid chemistry, are pleased to announce a new range of related products. These are detailed below and further details are available from Camida as the agents for Solvay Fluor. Looking beyond tomorrow's market needs, Solvay is continuously developing new CF3- products derived from trifluoroacetyl chloride; the newest member of this family is Ethyl-3-Amino-4,4,4-TrifluoroCrotonate (EATC), produced with a very high purity following our own technology (11). A new product line is also currently in the early stage of market introduction: CF2- building blocks. The key compound in this case is chlorodifluoroacetyl chloride (CDFAC). This line is produced similarly to the CF3- products. The large experience of Solvay's chemists and engineers in handling and manufacturing such compounds together with its unique technologies makes the company a competent and reliable partner for the development of new pharmaceutical and agrochemical products. Literature 1) SOLVAY Fluor & Derivate GmbH : EP 0659729, US 5569782 , JP 7206757, EP 0638539, US 5545298 and JP 7053446 2) SOLVAY Fluor & Derivate GmbH : EP 0623582, US 5405991, JP 7048316 and EP 0893426 3) SOLVAY Fluor & Derivate GmbH : EP 199072, US 4694112 and JP 61221139 4) SOLVAY Fluor & Derivate GmbH : EP 0623575, US 5481029 and JP 6321842 5) N. Lui, A. Marhold, M.H. Rock, Chim. Oggi 15 (1997), p.11-13 6) HOFFMANN LA ROCHE: DE 2806909 and JP 53103478 7) G.D. SEARLE & Co.: WO 9515316, EP 0731795 and US 5521207 8) Drugs of the future 23 (1998), p.133-141. DUPONT MERCK pharmaceutical co.: WO 9827034, WO 9827073 and WO 9845278 DUPONT PHARMACEUTICALS Co.: WO 2000000479 9) ROHM & HAAS: EP 0448544, US 5051512 and JP 4217664 10) BAYER AG: WO 9806706, WO 9823598 and WO 9827082 11) SOLVAY Fluor & Derivate GmbH : WO 9924390 Fmoc protected amino acid Camida can offer a new source of the following Fmoc protected amino acid, which can produce up to 5Kg per month. FMOC-Arg(PBF)-OHf)-OH (Na-Fmoc-NG-2,2,4,6,7-pentamethyldihydrobenzofuran-5-sulfonyl-L-arginine) Cas No.: 154445-77-9 Molecular formula: C34H40N4O7S Molecular weight: 648.78 The trifunctional guanidine side chain group of Arginine is strongly nucleophilic and, as such, is easily acylated during solid phase peptide synthesis if it is not protected. This sulfonyl based Argenine protecting group appears to give complete blocking of the guanidine side chain. Tapping the unique properties of South Africas precious metals A profile of Next Chimica, which distributes precious metal chemicals to over twenty countries worldwide for a variety of industry specific applications. Among the elements in the periodic table, precious metals, specifically the platinum group metals, have unique properties. These include the metals resistance to chemical corrosion and oxidation, and their catalytic properties. These qualities are exploited in the industrial applications of the precious metals, which include areas such as electroplating, electronics, mirrors, autocatalysts, cancer-treatment drugs, and catalysts in the petrochemicals industry. Industrial applications of the precious metals often require the metals in chemical form as a raw material, rather than in a metallic form. Here, the very properties that are exploited in the industrial applications of the precious metals sometimes make it difficult to convert the metals from the metallic form to precious metal chemicals. Precious metals have been produced in South Africa since the late nineteenth century. The refined metals have mostly been sold on the international precious metals market, generating a major proportion of South Africa's foreign revenues. Next Chimica is a leader in the downstream development of these metals. Founded in 1989, this Johannesburg-based company specialises in the manufacture of precious metal chemicals and the refining of precious metals. Over the past ten years, Next Chimica has developed the expertise needed to manufacture chemicals of the precious metals and to hold its own in the highly competitive and specialised international market for these products. At its manufacturing facility at Germiston, Next Chimica routinely manufactures between 40 and 50 of the most important precious metal chemicals and has the further capacity to supply a wide range of specialised precious metal chemicals on a custom-manufactured basis. The company serves more than 600 local and international clients in the automotive, industrial, petrochemical, electronics, medical and research sectors. To sell its products in Europe, the company has to comply with the requirements placed on European manufacturers, and compete with them on an equal footing. The same is true of all the other international markets. This means the company must be geared to comply with the most stringent industry standards anywhere in the world. To this end, Next Chimica recently developed and installed its quality management systems, covering every aspect of the firms operations, including areas such as pricing, delivery performance, responsiveness to customers concerns and requirements, and continuity of supply. Please contact Camida Ltd for more information on Next Chimica products. Examples of Camida products: Trans-3-(3-pyridyl) acrylic acid [19337-97-4] 4-Methoxybenzyl chloride [ 824-94-2] 2,2-Dithiosalicylic acid [119-80-2] Sodium amide [7782-92-5] 4-Bromophenylhydrazine [ 589-21-9] Phenyl chloroformate [1885-14-9] Benzophenone imine [ 1013-88-3] Dimethyl carbonate [616-38-6] 5-Norbornene-2,3-dicarboxylic anhydride [826-62-0] (3-isocyanatopropyl)-triethoxysilane [24801-88-5] 3-Acryloxypropyltrimethoxysilane [ 4369-14-6] STAB from Callery Chemicals Our US principal, Callery Chemicals, can offer high quality Sodium triacetoxyborohydride (STAB), as detailed in their advertisement opposite. Contact Camida for further information. Sourcing chemist Lisa Danels invites your enquiries. At Camida Ltd., we have always prided ourselves on being world leaders at finding reliable, cost-effective sources of starting materials and intermediates for the chemical industry. Todays purchasing departments face increasing pressure to reduce costs on raw material procurement and to find reliable, alternative sources for their key raw materials. It is in recognition of this fact that Camida Ltd have set up a technical sourcing department consisting of a dedicated team of two chemists. Receiving over 3,000 enquiries a year from our customers all over the world, the sourcing department utilises numerous strategies to find the best possible source for materials. These strategies include access to an extensive library, a collection of commercial databases and an exclusive internal database. It is often this internal database, which holds details of every enquiry ever received by the company that proves vital in the search. Camida Ltd is a founding member of the Indis Association which is key to its ability to identify reliable, cost-effective exotic sources for chemicals. Strong relationships with dependable manufacturers coupled with Camidas invaluable experience have led to their position at the forefront of chemical sourcing. As well as scouring for chemical entities, Camida Ltd also has a food division. We can offer stabilisers, sweeteners, flavours, vitamin/amino-acids, anti-oxidants and many more speciality ingredients at highly competitive prices. Scourcing of materials is a service provided FREE OF CHARGE to our customers. All enquiries (both costing and actual demand) are welcome; if possible, please include CAS number, quantity, and details of material specifications when submitting requests. For USA or UK-based enquiries, please contact lisa.daniels@camida.com; for Ireland or international-based enquiries, please contact yvonne.mullins@camida.com. So, let us take some of the strain, send your enquiries to Camida Ltd and give us the challenge of finding you high quality, reliable, cost-effective sources for your materials. US update from Kevin Dalton Well, I've earned a few air miles in my regular trips to the West Coast in 2001! It has been a pleasure meeting new contacts and discovering new companies; thanks also for taking the time to listen to our presentations and hearing about the great things we do. I look forward to heading south to warmer climates in February for the Informex Exhibition. We hope you will drop by our booth # 0425 and as always we will have the champagne on ice. We are teaming up with our partners, SynProtec, booth # 0427 on Wednesday 27th February, 6-9pm to host a riverboat dinner and music cruise aboard the ""John James Audubon"", so we look forward to a fun night with our valued customers and friends. Don't forget to drop by the booth on Wednesday if you haven't already received your invitation. We're going to post a few pictures of the night in the next issue so stay tuned! (kevin.dalton@camida.com) International update from John Geraghty Happy new year to all my customers! I hope you are all refreshed after the holidays and ready for another year of sending me many new and exciting enquiries. I am looking forward to another year of working with you all.... if its as good and challenging as last year it won't be too bad! My plans for this year are pretty similar to last: I will try to visit as many of you as possible. For those I dont get to visit, perhaps I will meet you at either CpHI or Chemspec, or if you are lucky perhaps at both! So, remember if you are looking for new sources of intermediates, R&D molecules, higher quality product, custom-made product or even if you are looking for a second source please do not hesitate to get in touch. (john.geraghty@camida.com) Examples of Camida products Tetraethylammonium iodide [68-05-3] (Ethyl)triphenylphosphonium bromide [1530-32-1] Tetraphenylphosphonium bromide [2751-90-8] Cetylpyridinium chloride [6004-24-6] Laurylpyridinium bromide [104-73-4] Cetyltrimethylammonium chloride [112-02-7] Cetrimide [8044-71-1] Tetramethylammonium hydroxide [75-59-2] 3-Amino-4-chlorobenzotrifluoride [ 121-50-6] 3-Aminobenzonitrile [ 2237-30-1] 4-Aminophthalide [ 3676-85-5] L-Penicillamine [1113-41-3] Congratulations to.... Breda O'Dwyer (Logistics) on her recent engagement to Vincent Colette Phelan (Administrator) on her recent engagement to Mick Lisa Daniels (Sourcing Specialist) on her recent engagement to Steve Sheila Gardner (UK) and husband Brian on the recent birth of their son, Jack. John Geraghty and Siobhán on their wedding in June (see photo opposite). Kevin Dalton (USA) and Tonya on their recent wedding (September).

Global Structure

2001/13/11

Global Structure

Sourcing / Supply

2001/13/11

Sourcing & Supply Global Reach: On the ground personnel in 20 countries 100,000 requests logged over past 15 years Product / process development With several specialist chemical and ingredient manufacturers ISO 9001, Responsible Care, PESP and PESP

Quality

2001/13/11

Responsible Care Responsible Care is an initiative developed by chemical companies to continuously improve environmental, health and safety performance of their operations and products in a manner responsive to the concerns of the public. ISO Camida endeavours to deliver product and service excellence in all aspects of interaction with customers and suppliers. The member companies are committed to the principles of "Responsible Care" and "ISO 9001". Our manufacturing facilities are designed to meet the scrupulous demands of the pharmaceutical industry. Quality systems are maintained, audited and improved to ensure that all personnel constantly strive to achieve the highest levels of accepted international standard. PESP The PESP document describes Camida's internal quality procedure for sourcing and supply of chemicals from locations other than Western Europe, USA, Canada and Japan. In addition to the standard vendor approval and review, for more exotic sources, it may at times be necessary to carry out supplementary vendor approval. This procedure is known as PESP (Pharmaceutical Exotic Sourcing Procedure) and is accommodated by Manufacturing Plant Summary (MPS) and a Pre-Audit Document (PAD). Additionally, Camida have in place procedures to ensure that such products from exotic location are inspected by the warehouse / clearing agent before onward delivery to the customer. The IGLO procedure outlines how Camida handles these inspections and documents the results and actions where required. GTDP Until 2005 GMP is limited to the manufacturing of finished medicinal formulation. From 2005 GMP is extended to cover certain manufacturers of raw materials used in production of medicines and :: Their Distributors: Good Trade & Distribution Practice

News Letter

2001/22/11

The Biotech boom is on With almost six years under my belt at Camida, I have seen my fair share of changes. In January 2000, I started in the Sourcing department of Camida and, 18 months later, moved into Sales covering the exciting export territory. These have been good years whizzing about the highways and byways of Europe and beyond. I am now on first name terms with most of the Hertz car rental people across Europe from Juan in Barcelona to Markus in Stockholm. In this time I have also managed to be at home enough to get married to my lovely wife Siobhan and have our beautiful baby boy Jamie. There has been one very big change in the industry as a whole: more and more biotechnology companies are appearing. The biotech boom is definitely on! On Febuary 28th 1953 James Watson and Francis Crick unveiled the secrets of the double helix structure of DNA. The biotech revolution stemmed from further discoveries in the 1970s where researchers discovered that it was possible to introduce genes into another organism so that it would make proteins. In industrial and university laboratories throughout the world, researchers are trying to get micro organisms to produce substances they would not secrete naturally. Biologists, microbiologists, biochemists and geneticists are exploring the mechanisms that control and regulate every living being on earth; men and animals, plants and bacteria. All of this will have incalculable consequences on the diagnosis and treatment of many diseases and the correction of genetic diseases. Camida can offer a wide range of products for this industry including products for oligonucleotide synthesis, peptide synthesis, cell culture, fermentation, purification of proteins and diagnostics. Camida will be focusing on this exciting sector in the next while. Please contact us if you require any further information. Camida and Lonza form agreement Camida has formed a new marketing agreement in Ireland with Lonza, the well-known high quality Swiss chemical and biotechnology company, in a move that enhances the range of specialised chemical facilities and products we can provide to our customers. Taking effect from January 2006, this strategic alliance applies to Lonza's non-GMP chemicals. Product groups included in this arrangement are: Diketene - derivatives HCN - derivatives Side chains Basic chemicals Non cGMP project acquisition More product details will be available in the next issue. Introducing New Team Members Lee Hassey, Logistics Lee Hassey joined the Logistics team in Camida in May of this year, having spent several years working in shipping, exports and logistics. He becomes yet another of the growing Waterford contingent slowly taking over Camida! His main interests outside of the workplace are gardening, photography; for leisure he also likes a good book or a good walk. He is looking forward to the many varied logistical challenges that Camida will present. Deirdre O'Grady, Finance Deirdre has been working in Camida's Finance Department since November 2004. Deirdre studied CIMA at Waterford Institute of Technology and has worked as an Accountant in the manufacturing sector since 1997. She travelled through Australia, China and South East Asia in 2001 and in her spare time plays camogie and follows all Gaelic games with a passion (up Wexford!) Deirdre has enjoyed her first year as member of the Finance Department and looks forward to her future at Camida. Camida supports Junction Festival Camida has been an on-going supporter and sponsor of the Clonmel Junction festival, which is now one of Ireland's fastest growing arts and cultural events. In its fourth year, Junction 7.05 drew huge crowds to Clonmel, - where Camida is headquartered - to a diverse line up of theatre, dance and music events from over 50 performers over nine days in July. Camida was the main sponsor for a performance by acclaimed Israeli ethnic musician Yair Dalal and his fellow percussionist and vocalist. A wonderful event. Tyzor® IAM (Phosphate type) - available since July 05 Description: DuPont™ TYZOR® IAM is a Butyl Phosphate Ethyl Alcohol, Isopropyl Alcohol Titanium Complex. CAS No. 109037-78-7 Benefits: TYZOR® IAM is a pale yellow solution of a titanium complex in a mixture of ethyl alcohol and isopropyl alcohol. TYZOR® IAM is useful as a low colour generating adhesion promoter in solvent based printing inks. It is also useful to promote cross-linking of the polymeric binder present in the printing ink which aids in the rate of curing of the ink. TYZOR® IAM is most effective when used at the 2 - 4% level in the printing ink. Typical properties of Tyzor®IAM Property Value Form Liquid Odour Fruity Colour Colourless to pale yellow % TiO2 14.3% % Ti 8.6% Specific gravity 1.00 @ 25O C Initial boiling point 80 C Flash point 12O C Pour point <-50O C Vapour Pressure 5.5Kpa @ 25O C Viscosity 20Mpa @ 25O C Solubility in solvents Miscible in most solvents Solubility in water Decomposes in water Methyltetrahydrofuran offers many favourable qualities; now available in commercial quantities MeTHF has the advantages of THF and Diethyl Ether in one solvent, according to Penn Chemicals. MeTHF has in the past been used only in select applications as an industrial solvent; however, it is now finding applications in many pharmaceutical and agrochemical synthetic processes. The primary reasons for this new interest are that producers have come to recognize that MeTHF has many of the favourable properties of both THF and diethyl ether (DEE) and that it is now available in commercial quantities from Penn's Plant in Memphis, Tennessee. THF is used in many organometallic reactions involving lithium, magnesium, zinc and tin. These reactions are typically followed by a water extraction step to remove the large amount of generated metal salts. MeTHF can be substituted for THF in these organometallic reactions with the advantage that it can be used as both the reaction solvent and the product isolation solvent. Unlike THF, MeTHF is only partially water-soluble so it can function both as the polar reaction solvent and the solvent for product isolation. MeTHF can be especially useful in a process that has several consecutive reaction and water separation steps. In these processes, the favourable MeTHF-water azeotrope makes it possible to dry the product with MeTHF before the next reaction step. MeTHF gives very clean water phase separations in the product recovery step. With THF, toluene is often added to the product recovery step and the toluene can cause formation of emulsions or rag layers. The properties in the table below show that MeTHF lies between DEE and THF in Lewis base strength and solvent polarity. MeTHF can be used like DEE in organometallic reaction and product recovery steps without incurring the risks of using a hazardous volatile solvent like DEE. When used as a solvent in Grignard chemistry, MeTHF and THF give similar results in forming and reacting with most Grignard reagents. However, MeTHF can be used to form much higher concentrations of bromo and iodo Grignard reagents because MgBr2 and MgI2 are much more soluble in MeTHF than in THF. In addition, MeTHF can be used to form high yields of benzyl and allyl Grignard reagents whereas these reagents are difficult to produce in THF. Application studies at Penn have shown that MeTHF is a very efficient solvent for extracting water-soluble and partially water-soluble compounds from water mixtures. Penn can provide interested customers with details on the behaviour of MeTHF as an extraction solvent in water systems and can provide engineering designs for the recovery and drying of MeTHF. Camida acts as agents for Penn Speciality Chemicals. For further information, contact John McNeille in the UK (john.mcneille@camida.com) and Órla Heenan in Ireland (orla.heenan@camida.com). CPhI - Food for Thought! Camida has taken the opportunity of this year's CPhI location in Madrid to upgrade the now traditional 'Camida dinner out at CPhI'. We are inviting our guests this year to an evening's dining out in 'Privado de la Terraza Room', Casino de Madrid. Looking forward........... In Casino de Madrid gastronomy has always been a form of union between healthy expression and the 'tertulia' (social gathering). From the very hand of Ferran Adria (of El Bulli, Michellin three stars), gastronomic assessor of the Casino, and his oustanding disciple Paco Roncero, head chef, come the best prepared gastronomic delights. Exhibition news Please come see us at: CPhI Madrid, 1-3 November 2005. Stand No.: 10J32 Hall 10 (see above!). Surfex at G-Mex Manchester 21-22 June 2006. No official stand number yet. Informex 2006. Due to the hurricane disaster in New Orleans, Informex will be moved to a new venue. More details in next newsletter. Congratulations to....... Lisa Daniels Lisa Daniels, Sourcing Specialist, and her husband Dr. Steven Ball, are celebrating the birth of their first child, Róisín. Kevin Dalton Kevin Dalton, North America Sales Manager, and his wife Tanya, are celebrating the birth of their second child, Conor. Get in touch! Camida offices are open weekdays from 08.00 hrs to 17.30 hrs except for Christmas and Easter. Camida is a global company and is therefore open for your service and enquiries on all other public and bank holidays. Ring us anytime! Camida Americas - Ph: +1 973 645 9227 Camida Asia - Ph: +65 6738 7311 Camida Europe - Ph: +353 52 25455 E: info@camida.com - W: www.camida.com Silane coupling agents from Shinetsu ShinEtsu's wide range of silane coupling agents improve the functionality and quality of material and gives wide possibilities to develop many new products. Silane coupling agents are silicon-based chemicals containing two types of reactivity - inorganic and organic - in the same molecule. A typical general structure is Y-Si(Or)3 where Or is a hydrolyzable group such as methoxy, ethoxy, or acetoxy, and Y is an organofunctional group such as amino, methacryloxy, epoxy, etc. Silane coupling agents act as a link between an inorganic substrate and an organic material. A simplified picture of the coupling mechanism is shown below. The organic functional groups bond to silicone atoms via alkylene groups, which are chemically and thermally stable, and when applied to composite materials they bring excellent reinforcement properties and heat resistance. When selecting which functional group to use, it is crucial to consider whether the purpose is to bond an organic material to the inorganic material surface or to make the inorganic surface compatible, as this contributes greatly to improving the properties of the composite material. Our silane coupling agents can boost the mechanical strength, improve moisture resistance and adhesion, and provide resin modification and surface modification to improve the functionality and quality of a wide range of materials. Newly developed silane coupling agent KBM-5103 (3-acryloxypropyltrimethyoxysilane) is an excellent adhesion promoter and reinforcing agent, as shown below. KBM-5103 having a highly reactive acrylic group is a very useful modifier for many high performance products including optical fibres, acrylics, epoxies and composites. Acryloxy group is significantly more reactive than methacryloxy group (KBM-503) and at the same time acryloxy-silane was found to condense more slowly than its analog, which enhances storage stability (see Figure 3). This silane agent can be applied as reinforcement of artificial marble, additive to UV/EB curable resins and inks, and as an excellent modifier for acrylic resins. In comparison with methacryloxysilane, KBM-5103 also improves the bonding strength of unsaturated polyester laminates, as shown below. Camida acts as agents for ShinEtsu. For further information, contact Noel Hastings (noel.hastings@camida.com).

Issue 29

2003/20/01

A heady mix of pressure and excitement ..... Órla Heenan considers recent changes and current developments Since I last wrote two years ago, life at Camida has been a heady mix of pressure and excitement following our consolidation. It has also been a time when, through the natural maturing process, we have had some personnel changes; it has been quite amazing to see our newer staff members slotting in so quickly, rowing in with the swell of change in our organisation, all the while learning the ropes themselves. New people also bring new ideas and new partnerships, and we have seen a growing strength in each and every department. Now that life has settled down again (....dare I say it!), for the past six months or so we have focused on revising and improving our ISO Quality system. This project has been led by Deirdre McGrath who deserves great credit for the care that she has taken, co-ordinating the suggestions and contributions from the various departments and directing the procedures into place. Sometimes a quality system can be a burden, but I can undoubtedly say that the greatest burden is on the co-ordinator. Now that we are finished and await our audit in November, it's great to already see the benefits that this 'extra' work will bring to our operating system. So a big 'thank you' to Dee for all her hard work and dedication .....not to mention her patience! For my part at Camida, I am thoroughly enjoying my responsibility for the Irish market and appreciate the help and support that David still provides daily. In the past two years, the introduction of our dedicated sourcing team makes the sales role easier and more efficient in terms of replies to enquiries. Many of our customers received our Quality Questionnaire in June this year. We read with interest each and every reply that we received. Your comments, criticisms and your praise help us evaluate what we need to do to improve further. It's also lovely to hear the nice and amusing things that you have to say about us as well ...... real encouragement in a sometimes very cynical world. The truth is that many of us here in our 'small' company actually love what we do; we don't always get everything right, but in each of us there is a strong desire to do well and provide a really excellent service to our customers. Looking forward.......... MCT: Innovation and precision in catalyst technology and production We take a closer look at MCT- Raney® type nickel, cobolt & copper catalyst specialists, daughter company of London Scandinavian Metallurgical Co. MCT's state-of-the-art catalyst production plant, built in 2000, nestles between the river and the golf course in Rotherham, South Yorkshire, England. The plant has the most modern computer control to ensure the consistency of catalyst batches. MCT has already been awarded ISO 9001 certification, together with approvals to Kosher and Halaal standards, enabling the catalysts to be used in food and pharmaceutical processes across the world. These MCT Raney ® catalysts are being sold throughout Europe under the trade name of METCAT. The catalysts - mainly nickel, cobalt and copper - are available in any particle size to suit customer requirements and also with additional promoters to enhance or control specific reactions. Bespoke catalysts are readily produced because of the backward integration of MCT into the parent company - London Scandinavian Metallurgical Co (LSM), which enables the ready incorporation of special elements. Raney ® catalysts are employed in a variety of reactions, including hydrogenation of alkynes, alkenes, nitriles, carbonyls and aromatics and also reductive alkylations, aminations and dehydrogenations. Camida (Ireland) represents MCT in Ireland and Camida LLC represents MCT in USA. The reaction of potential customers has been very positive (see Kevin Dalton's report opposite). The catalyst plant is open to all customers to visit and view in person, or by visiting the MCT website, www.metcat.com, clicking the 'plant' page, entering an email address, and downloading a ten-minute explanatory video, showing the production of alloys and catalysts Please contact Camida for further information on MCT products. MCT catalysts are employed in the complete spectrum of organic chemical reactions, examples include; Hydrogenation of: aldehydes alkenes alkynes aromatics carbonyls heterocyclics nitriles nitro-groups solvents sugars terpenes waxes Reductive Amination of: alcohols aldehydes Reductive Alkylation of: primary amines secondary amines Hydrogenolysis of: esters ethers Dehydrogenation of: alcohols hydrocarbons Hydration of: Nitriles Removal of: halogens sulphur species Purification of: greases olefins International sales update John Geraghty, International Sales Manager, reports on his first full year as a sales person Hello all from international sales.... one year on, and it's still going well! I have made quite a lot of good contacts over the year; hopefully, I can develop these more and provide the service that you should expect. I know that there is still quite a lot of potential out there, so if you are involved in purchasing and happen to be reading this, please drop me an email and let's see what we can do! I am still travelling to visit as many of you as possible and getting to the trade shows. I met several customers at Chemspec (....it was nice to get to a part of the world where you could at least see some sunshine and leave the umbrella behind!). CPhI Paris is rapidly approaching; by the time you read this, I will have organised meetings with many of you. Remember, if you are looking for new sources of intermediates, R&D molecules, higher quality product, custom made products or even if you are looking for a second source, please do not hesitate to contact me (john.geraghty@camida.com). So, until Paris, or wherever, .....au revoir! Global quality supply of intermediates We have all been there! A price and a specification from a source the other side of the globe looks irresistible. Even the sample looks OK. Later, however, things start to go wrong &.perhaps it was not produced in the factory you thought; the plant itself turns out to be a nightmare; the end-product is guessed to be correct; the yellow effluent runs into the river; the local authority is about to close the plant down. These are just some of the many possible scenarios. Camida has now formally introduced a means of preventing such situations into its latest ISO 9002 procedures. The procedures are referred to as PESP (Pharmaceutical Exotic Sourcing Procedures). In future, all our customers will have the option of sourcing intermediates from 'exotic locations' using these techniques. Basically, through a series of documentation, questionnaires, visits, audits, etc., using Camida personnel and their global partners, steps are taken to ensure that our customers only evaluate materials at an early stage from factories that will eventually stand up to a fairly rigorous audit. Plants are categorised with a score at the various stages of supply, which means the Camida dossier of acceptable plants from around the world is being continuously updated. If you would like to learn more about PESP, feel free to discuss with your local Camida representative. Callery Chemicals develops new process for cleaner reactions Solvay Fluor: new developments Trifluoroacetamide (TFAA) and N-Methyltrifluoroacetamide (NMe-TFAA) are now available from Solvay Fluor. These compounds can be used in peptide chemistry for introducing a trifluoroacetyl-protecting group directly into an organic intermediate. Alternatively a protected amino group could also be made using Trifluoroacetic acid anhydride (TFAH). All these compounds are manufactured in a new CF3/CF2-multipurpose plant in Solvay Fluor's Bad Wimpfen plant located near Stuttgart, Germany. In addition, Solvay Fluor has Ethyl-3-Amino-4,4,4-trifluorocrotonate and the N-methyl derivative (EATC, NMe-EATC) and Ethoxy-4,4,4-trifluoro-2-butene-3-one (ETFBO) in the development pipeline. These compounds are CF3-building blocks for new classes of agrochemicals. Camida LLC's Kevin Dalton on MCT I recently travelled with Eddie McCrudden, business manager of MCT, to Texas, to present MCT to the petrochemical industry there. I was impressed by MCT's dedication to custom service and the company's innovativeness in catalyst technology - I can tell that it is very much welcomed. We are also working closely with the pharma and fine chemical industry and we will continue to provide custom catalyst samples for new process development projects. Any contract manufacturers using loop reactors might also want to consider a new MCT catalyst that will further improve the efficiency of their process. If your process chemists would like to receive a presentation on MCT, or if you need catalysts samples, please do not hesitate to get in touch: kevin.dalton@camida.com CPhI beckons! We look forward to meeting many of our customers and friends at the CPhI Worldwide Exhibition from 1st to 3rd October in Paris, France. You will find Camida at Stand F87, Hall 1- do drop by! Looking ahead, Camida will also exhibit at Informex which takes place in New Orleans from 25th to 28th February 2003. New sales manager for food & ingredients... Richard Sheehan has taken over as sales manager of the Food & Ingredients Division from Donald McDonagh who, as customers will be aware, has moved to 'new pastures'. Richard will initially focus on familiarising himself with Camida's existing Principals and customer base, while expanding and developing the current range of products to meet the ever changing challenges faced by manufacturers and processors in the food and drink industries. He is ably assisted by Yvonne Mullins (Sourcing Specialist) and Colette Phelan (Logistics). Richard has many years of experience within the Food Industry, having spent the last five years in business development, promoting a wide range of food ingredients into the manufacturing/processing, bakery and catering industries. He graduated as a chef from the Dublin College of Catering in 1986, and went on to win many culinary awards while pursuing his career both in Ireland and in Canada. He lives in County Laois with his partner and three children. Richard's interests include cooking, reading, psychology, and motor sports. Selected new Camida products D-Alaninol [35320-23-1] 1,3-Dibromobenzene [108-36-1] Tetrahydropyran [142-68-7] 1-H-1,2,4-Triazole-3-carboxamide [3641-08-5] 3-Amino-1,2,4-triazole-5-carboxylic acid [3641-13-2] Osmium tetraoxide [20816-12-0] 4-Cyanobenzaldehyde [105-07-7] Dimethyl carbonate [616-38-6] Oxalyl chloride [79-37-8] Chlorotriphenylmethane [76-83-5] 2,3-Dichlorobenzaldehyde [6334-18-5] 3-Hydroxypropionitrile [109-78-4] Cis-2,6-Dimethylmorpholine [6485-55-8] 2-Chloro-3-cyanopyridine [6602-54-6] Ethyl 2-aminobenzoate [87-25-2] Phenyl acetonitrile [104-29-4] 4-Anisidine [104-94-9] Diethylmalonate [108-59-8] 5-Cyanophthalide [82104-74-3] (2-Bromoethyl)benzene [103-63-9] Logistics: looking after the essential details Logistics ...a simple word but a task that requires meticulous dedication and tenacity. Our logistic team steps into action from the time an order is received, and strives to look after every detail of delivery however big or small. This dedicated team monitors all aspects of transport from door to door, and is responsible for ensuring that the customer receives all the required documentation for their delivery. With our newly revised ISO system in place, each member of that team operates to the same standard. They take on board each customer's particular requirements and always do their best to ensure that deliveries will comply. Our team is involved daily with arranging transportation of goods from all over the world to any destination. They strive to deliver goods to you on time, dealing with any disturbances en route and keeping you, the customer, informed as best as possible. Do not hesitate in contacting Breda, Nicola, Susan, Catriona or Colette if you have any queries about any aspect of the order process. The people behind the voices... Here are the people, who joined us in recent months, that you may come into contact with in your dealings with us: Claire Lambert Claire joined Camida in May this year after completing a business and secretarial course in The Central Technical Institute, Clonmel. This is Claire's first full time position and she looks after our reception and administration needs. Claire is a fine footballer and with Co. Tipperary won the national league title this year. Aside from football, she also likes to swim, socialise and is interested in music. Yvonne Mullins Yvonne graduated in 2001 from University College Dublin (UCD) with a B. Sc. (Hons.) in Chemistry. Joining Camida's sourcing team is her first venture after college. Her interests include basketball which she plays competitively, reading, swimming & watching all Gaelic games particularly hurling (Up Kilkenny, she says!). The banter between the Waterford, Tipperary & Kilkenny contingent in our office this hurling season has been interesting to say the least! Gillian Veale Gillian has been working in Camida's Finance Department since February 2002. Gillian studied CIMA at Waterford Institute of Technology, before moving to London where she was based for over three years. She has a keen interest in sports & travel, and joined Camida after one year spent travelling in Australia, New Zealand & South East Asia. Nicola Ward Nicola moved from the UK 18 months ago to sample life in Ireland where she has relatives. She joined Camida's logistics team in November 2001 and is responsible for John McNeille's customers in the South UK. From September, she will also look after Allan's customers in the North UK whilst Catriona is on maternity leave. Nicola loves socialising, shopping & sunshine, she says! Breda White Breda joined Camida's Finance Department in May 2002. Having worked in Cork for a number of years, Breda moved back to Tipperary in July 2001. She has one little boy called Cillian. Breda enjoys cooking, and believes, in time, that gardening will become her new pastime! Wedding congratulations Lisa Daniels, Sourcing Chemist, celebrated her wedding to Dr. Steven Ball in March 2002. Congratulations and a happy life to both!

Issue 28

2003/20/01

Four years on, McNeille reflects John McNeille reflects on the World Cup, and other matters! It is now more than four years since I joined Camida and once again I find myself challenged with what to write in this editorial. It only seems a very short time ago when I had more hair and the World Cup was taking place in France; we are now about to see the tournament being held in Japan and Korea during 2002 - good luck to England and Ireland !!!!!!!!!!!! (Although I am English I would face a certain lynching from my Irish colleagues if I did not wish the team from Ireland good luck as well). As with so many businesses several changes have taken place within our group over the last four years, such as changing the names of all our group companies to Camida as well as combining our logistics, accounts and chemical sourcing operations into one location in Clonmel while still maintaining local sales activities and stock holding. We are now seeing the benefits of centralising our administration in Ireland where we continue to strive to provide an excellent service for our customers and principals. We recently attended the CPhI exhibition in London where it was great to meet many of our customers, friends and suppliers from around the world and of course we look forward to seeing many of you again at Informex in New Orleans during February. On the people front, I would also like to extend a warm welcome to Yvonne Mullins who has joined our sourcing team (see page 2), and to Nicola Ward who recently joined our logistics department and who will be looking after my customers and their orders. We will be letting you know more about Yvonne and Nicola in future issues. I have really enjoyed my first four years with Camida and I look forward to continuing to help build on the strengths of our team and organisation to keep growing our business. New Silane Coupling Agents from Shin-Etsu: KBM-5103 & KBE-9007 KBM-5103 is a silane coupling agent, newly developed from Shin-Etsu as an adhesion promoter and reinforcing agent.Its acryloxy group is significantly more reactive than the corresponding methacryloxy group on KBM 503. Applications include the reinforcement of artificial marble, as an additive to UV/EB curable resins and inks and is also a modifier for acrylic resins. KBM-5103 improves the bonding strength of unsaturated polyester laminates. Qualities Chemical Name: 3-Acryloxypropyltrimethoxysilane Structural Formula: CH2=CHCOO(CH2)3Si(OCH3)3 General Properties (not specifications) Viscosity at 25oC: 2.3mm2/s Specific gravity at 25oC: 1.06 Refractive index at 25oC: 1.427 Boiling point: 100o C/4mm Hg Flash point: 115o C CAS No: 4369-14-6 Also available from Shin-Etsu is their silane coupling agent KBE-9007. KBE-9007 is 3-Isocyanatopropyltriethoxysilane, which has applications in urethane adhesives and sealants. For further information on any of these products, please contact Camida Ltd. See you at Informex 2002! Well be in New Orleans from 26th February to 1st March at Booth # 0425. Attending from Camida are David Anchell, Allan Hughes, Órla Heenan, and Kevin Dalton. SynProTec will be at Booth # 0427. Attending from SynProTec are Peter Nightingale and Ian Scanlan.

Contact Us

2001/15/11

Ireland CAMIDA Ltd Tower House New Quay Clonmel Co. Tipperary Ireland Tel +353-52-25455 Fax +353-52-25466 info@camida.com Managing Director : David Anchell david.anchell@camida.com Sales Director : Orla Heenan orla.heenan@camida.com Group Financial Director : Bernard Pollard bernard.pollard@camida.com International Sales Manager : John Geraghty john.geraghty@camida.com Food Ingredients Manager : Richard.Sheehan richard.sheehan@camida.com Co. Secretary/Office Manager : Deirdre McGrath deirdre.mcgrath@camida.com Sourcing Specialists : Lisa Daniels lisa.daniels@camida.com, Jacqueline Dee jacqueline.dee@camida.com & Yvonne Mullins yvonne.mullins@camida.com Logistic Administrators : Lee Hassey lee.hassey@camida.com, Colette Phelan colette.phelan@camida.com, Laura West-Burnham laura.west-burnham@camida.com, Nicola Ward nicola.ward@camida.com. United Kingdom CAMIDA Ltd Willow Mill Caton Lancaster, LA2 9RA United Kingdom --> Tel +44-1524-771881 Fax +44-1524-771882 info@camida.com Sales Manager : John McNeille john.mcneille@camida.com Sales Manager : Noel Hastings noel.hastings@camida.com USA CAMIDA LLC One Gateway Centre Suite 2600 Newark, New Jersey 07102 Tel +1-973-645-9227 Fax +1-973-645-9484 info@camida.com Sales Manager : Kevin Dalton kevin.dalton@camida.com Singapore CAMIDA Pte Ltd, 15 Beach Road, #03-08/10 Beach Centre, Singapore 189677 Tel: + 65 6738 7311 Fax: +65 6738 7313 info@camida.com CAMIDA Holdings Ltd Tower House New Quay Clonmel Co. Tipperary Ireland Tel +353-52-25455 Fax +353-52-25466 info@camida.com

Product Categories

2003/15/04

Organic Intermediates Reagents Organometallics Inorganic Salts Catalysts Precious Metals Biochemicals Speciality / Effect Chemicals Speciality Solvents Natural Extracts Active Pharmaceuticals Substances (API's) Pharmaceutical Excipients Food Ingredients Nutraceuticals Food Flavours Food Colours

Our Organisation

2003/17/04

Our Organisation * click a name to send an e.mail --> -->

Photo Gallery

2003/17/04

Photo Gallery Click on an image below to enlarge it.

Core Competencies

2003/08/05

Camida's Core Competencies

INDIS

2003/08/05

INDIS Camida is a founder member of the INDIS Associates worldwide. INDIS stands for International DIStribution. Through INDIS, the Group has many overseas associates with companies in Australia, Belgium, Canada, China, the Czech Republic, Finland, France, Germany, Hungary, India, Ireland, Italy, Japan, Korea, Malaysia, New Zealand, the Philippines, Taiwan, Singapore, South Africa, Venezuela, the UK and the USA. The INDIS organisation gives Camida international sourcing and purchasing power for customers and an international distribution network if required by the group's principals.

CDI

2003/08/05

CDI Chemical Distribution Ireland (CDI) was formed in 1984 to strive to ensure that member companies understand and contribute to best practices within the industry and its environment. The Association is affiliated to the Irish Business and Employers Confederation and is a member of the European Association of Chemical Distributors (FECC) All sectors of the chemical industry have a role to play in ensuring the safe storage, transport and manufacture of chemical products with due respect for our environment, for it is on this that the future of our industry depends. It has been CDI which has been to the fore in Europe in implementing the environmental performance management tool and world wide initiative that is Responsible Care. CDI was the first European Chemical Distribution Association to implement this mandatory requirement in 1999. All members must undergo an external audit of the Responsible Care Programme which is based on the eight primary guiding principals. A key principle is a commitment to ongoing improvement, so the Association has already moved on to Phase 2 of the Responsible Care Programme incorporating site verification audits. CDI also works closely with the Irish Pharmaceutical and Chemical Manufacturers Federation (IPCMF) on items of mutual interest, such as co-operation in ongoing improvements to emergency response capabilities. CDI has other important active working groups in communications and packaging and work closely with Repak to achieve recognition for the high level of recycling, recovery and reuse of packaging in our industry.

Products

2003/08/05

Products Organic Intermediates Reagents Organometallics Inorganic Salts Catalysts Precious Metals Biochemicals Speciality / Effect Chemicals Speciality Solvents Natural Extracts Pharmaceutical Excipients Nutraceuticals Active Pharmaceutical Substances (API's) Food Ingredients Moisture Scavengers Plasticizers

Ireland

2003/08/05

IRELAND Camida's core activity is sourcing and supply of specialised chemical products to the pharmaceutical manufacturing industry. Sixteen of the world's top twenty pharmaceutical companies now have manufacturing sites in Ireland. This makes Ireland a very appropriate choice for the location of Camida's Group headquarters. Camida HQ is situated in Tower House, Clonmel where several functions for the group are centralised. These functions include Finance, Logistic, Technical Support, Management and Sourcing. The pharmaceutical and chemical industry has become a powerful engine of growth in the Irish Economy. Their combined output is over EUR 40 billion or approximately 30% of Ireland's exports. The character of the Irish Chemicals Industry is quite different to that in other countries, where it has grown out of heavy chemical processing activities. There is virtually no petrochemical activity at all in Ireland and only a small number of bulk commodity producers. Instead the focus is on small, clean and high value, fine chemical and pharmaceutical operations. The number employed are low related to the economic output - only a little over 20,000 directly. About half of those currently employed however have a third level qualification. Prospects for the future remain good with current capital investment of about EUR 1 billion each year. This being a combination of expansion of current operations and construction of green field sites. Camida is a service based company sourcing and supplying specialised chemical products to this industry. Camida is actively involved with all pharmaceutical and related manufacturing companies in Ireland. Ireland remain Camida's most important single market place. Camida personnel dedicated to and supporting the Irish market include: Orla Heenan Sales Director Eileen McAree Sourcing Breda O'Dwyer Logistics (click on image to send personnel e.mail)

International

2003/08/05

International The export department of Camida covers all territories outside Ireland, the UK, Singapore, North America and Canada. John Geraghty is the sales manager responsible for this market. The main products offered are "hard to find" chemicals such as Organic Intermediates, fine chemicals, biochemicals, organometallics, polymers, adhesive raw materials and speciality and performance chemicals. These products can be sourced for a wide range of industries including Pharmaceutical, Biotechnology and Industrial. Products sourced can be kg quantities for research and development up to any quantity for commercial supply. The international department is serviced by the following people: John Geraghty Sales Eileen McAree Sourcing Laura Reidy Logistics (click on image to send personnel e.mail)